Ontology highlight
ABSTRACT:
SUBMITTER: Wrensch F
PROVIDER: S-EPMC4564551 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Wrensch Florian F Karsten Christina B CB Gnirß Kerstin K Hoffmann Markus M Lu Kai K Takada Ayato A Winkler Michael M Simmons Graham G Pöhlmann Stefan S
The Journal of infectious diseases 20150601
Ebolaviruses are highly pathogenic in humans and nonhuman primates and pose a severe threat to public health. The interferon-induced transmembrane (IFITM) proteins can restrict entry of ebolaviruses, influenza A viruses, and other enveloped viruses. However, the breadth and mechanism of the antiviral activity of IFITM proteins are incompletely understood. Here, we employed ebolavirus glycoprotein-pseudotyped vectors and ebolavirus-like particles to address this question. We show that IFITM prote ...[more]