Systematic stereoscopic analyses for cloacal development: The origin of anorectal malformations.
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ABSTRACT:
SUBMITTER: Matsumaru D
PROVIDER: S-EPMC4564729 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Systematic stereoscopic analyses for cloacal development: The origin of anorectal malformations.
Matsumaru Daisuke D Murashima Aki A Fukushima Junichi J Senda Syuhei S Matsushita Shoko S Nakagata Naomi N Miyajima Masayasu M Yamada Gen G
Scientific reports 20150910
The division of the embryonic cloaca is the most essential event for the formation of digestive and urinary tracts. The defective development of the cloaca results in anorectal malformations (ARMs; 2-5 per 10,000 live births). However, the developmental and pathogenic mechanisms of ARMs are unclear. In the current study, we visualized the epithelia in the developing cloaca and nephric ducts (NDs). Systemic stereoscopic analyses revealed that the ND-cloaca connection sites shifted from the latera ...[more]
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