Response and acquired resistance to everolimus in anaplastic thyroid cancer.
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ABSTRACT:
SUBMITTER: Wagle N
PROVIDER: S-EPMC4564868 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Response and acquired resistance to everolimus in anaplastic thyroid cancer.
Wagle Nikhil N Grabiner Brian C BC Van Allen Eliezer M EM Amin-Mansour Ali A Taylor-Weiner Amaro A Rosenberg Mara M Gray Nathanael N Barletta Justine A JA Guo Yanan Y Swanson Scott J SJ Ruan Daniel T DT Hanna Glenn J GJ Haddad Robert I RI Getz Gad G Kwiatkowski David J DJ Carter Scott L SL Sabatini David M DM Jänne Pasi A PA Garraway Levi A LA Lorch Jochen H JH
The New England journal of medicine 20141001 15
Everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), is effective in treating tumors harboring alterations in the mTOR pathway. Mechanisms of resistance to everolimus remain undefined. Resistance developed in a patient with metastatic anaplastic thyroid carcinoma after an extraordinary 18-month response. Whole-exome sequencing of pretreatment and drug-resistant tumors revealed a nonsense mutation in TSC2, a negative regulator of mTOR, suggesting a mechanism for exquisite sensiti ...[more]
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