Dataset Information

Polymorphisms in the nuclear excision repair gene ERCC2/XPD and susceptibility to cutaneous basal cell carcinoma.

ABSTRACT: Studies have investigated the relationship between XPD Lys751Gln and Asp312Asn genetic variants and risk of cutaneous basal cell carcinoma (BCC). However, the results remain inconclusive. We performed a meta-analysis, using a comprehensive strategy based on the allele model and a model-free approach, to investigate the association of between XPD Lys751Gln and Asp312Asn polymorphisms with BCC risk. For XPD Lys751Gln, no significant BCC risk was found in the allele model (OR = 0.97, 95% CI 0.90-1.04, I (2) = 35.3%, P heterogeneity = 0.125) and with model-free approach (ORG = 0.95, 95% CI 0.87-1.04, I (2) = 15.9%, P heterogeneity = 0.296). For XPD Asp312Asn, there was also no association between this polymorphism and BCC risk in the allele model (OR = 0.94, 95% CI 0.86-1.03, I (2) = 0, P heterogeneity = 0.650) and with the model-free approach (ORG = 0.94, 95% CI 0.85-1.05, I (2) = 0, P heterogeneity = 0.603). Therefore, this meta-analysis suggests that the XPD Lys751Gln and Asp312Asn polymorphisms were not associated with BCC risk. Further large and well-designed studies are needed to confirm these findings.

SUBMITTER: Sun Y

PROVIDER: S-EPMC4565234 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Polymorphisms in the nuclear excision repair gene ERCC2/XPD and susceptibility to cutaneous basal cell carcinoma.

Sun Ying Y Liu Zhihong Z Liu Ying Y Li Xia X

International journal of clinical and experimental medicine 20150715 7

Studies have investigated the relationship between XPD Lys751Gln and Asp312Asn genetic variants and risk of cutaneous basal cell carcinoma (BCC). However, the results remain inconclusive. We performed a meta-analysis, using a comprehensive strategy based on the allele model and a model-free approach, to investigate the association of between XPD Lys751Gln and Asp312Asn polymorphisms with BCC risk. For XPD Lys751Gln, no significant BCC risk was found in the allele model (OR = 0.97, 95% CI 0.90-1. ...[more]

PMID: 26379851

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Project description:Background Recurrence of basal cell carcinoma (BCC) after complete surgical excision is rarely reported. Risk factors for this negative outcome are not well-studied. We present the clinical and histological features of recurrent BCCs in our institution. Methods All patients between January 2016 to December 2020 whose primary BCCs were excised with free surgical margins according to the histopathology report, and represented later with local recurrence were included. The medical files were retrieved to record patient's age, sex, sun exposure, tumor site, size, clinical diagnosis, histopathology variant of primary lesion, least free margin distance of the original lesion, and recurrence time. Results Eighteen patients (11 males and 7 females ranged between 50 and 75 years old) fulfilled the inclusion criteria; all of their lesions were located in head and neck regions. The mean recurrence time was 31.2 months (11–86) and the histological variant was the same of primary in 17/18 patients. Primary tumors showed nodular subtype in 77.8% of patients and 55.6% of the primary tumors were less than 15 mm in diameter. Sun exposure history was given by 77.8% of patients while the rest of patients had non-significant exposure. All recurrent excised lesions were of free margin less than 4 mm. Conclusion We found that the primary tumors of all studied recurrent BCCs were excised with surgical margins less than 4 mm. We recommend follow up for all excised BCCs either those of low or high risk histological variants. Tumor size does not appear a considerable risk factor for local recurrence. Highlights • We report recurrent BCCs in 18 patients, all were located in head and neck region.• Sun exposure history was given by 77.8% of patients while the rest of patients gave a negative history of sun exposure.• Nodular histological subtype was seen in 77.8% of patients.• All primary tumors were excised by general or plastic surgeons with a surgical margin less than 4 mm.

Dataset Information

Polymorphisms in the nuclear excision repair gene ERCC2/XPD and susceptibility to cutaneous basal cell carcinoma.

Publications

Polymorphisms in the nuclear excision repair gene ERCC2/XPD and susceptibility to cutaneous basal cell carcinoma.

Similar Datasets

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