Dataset Information

Can the peak E2/follicle ratio be a quantitative indicator of pregnancy outcomes following assisted reproductive cycles? A retrospective study.

ABSTRACT: As one of the limited reference parameters for the appropriate timing of human chorionic gonadotropin (hCG) priming and embryo transfer (ET), peak serum estradiol (E2) level and related parameters have been considered to be a possible marker of in vitro fertilization (IVF) outcomes. To our knowledge, few reports have investigated the correlation between the ratio of peak serum E2 to the number of follicles ? 14 mm on the day of hCG administration (i.e., the E2/fol. ratio) and the miscarriage rate (MR) in assisted reproductive cycles. In this study, a total of 1376 cycles were examined and grouped into quartiles by E2/fol. ratio. The patient characteristics, controlled ovarian hyperstimulation (COH) performance, and IVF/ICSI results were compared between the four groups. Patients were further categorized as younger than 35 years of age or 35 years of age and older. The association between the E2/fol. ratio and the implantation rate (IR) or MR was examined using the Mantel-Haenszel test for each group. We found that the E2/fol. ratio correlated with the IR and MR for women younger than 35 years of age. There was a statistically significant increase in the IR with E2/fol. ratio between 279.83 and 552.28 pg/ml, and women with an E2/fol. ratio > 552.28 pg/ml were more likely to suffer miscarriages. Our data support a role for cryopreservation of all embryos when E2/fol. ratio exceeds 552.28 pg/ml for women younger than 35 years of age.

SUBMITTER: Hu D

PROVIDER: S-EPMC4565274 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Can the peak E2/follicle ratio be a quantitative indicator of pregnancy outcomes following assisted reproductive cycles? A retrospective study.

Hu Dan D Dong Xiyuan X Xiong Min M Xiong Ting T Huang Bo B Zeng Dan D Ai Jihui J Zhang Hanwang H

International journal of clinical and experimental medicine 20150715 7

As one of the limited reference parameters for the appropriate timing of human chorionic gonadotropin (hCG) priming and embryo transfer (ET), peak serum estradiol (E2) level and related parameters have been considered to be a possible marker of in vitro fertilization (IVF) outcomes. To our knowledge, few reports have investigated the correlation between the ratio of peak serum E2 to the number of follicles ≥ 14 mm on the day of hCG administration (i.e., the E2/fol. ratio) and the miscarriage rat ...[more]

PMID: 26379891

Similar Datasets

Project description:Live-birth rates after treatment with assisted reproductive technology have traditionally been reported on a per-cycle basis. For women receiving continued treatment, cumulative success rates are a more important measure.We linked data from cycles of assisted reproductive technology in the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for the period from 2004 through 2009 to individual women in order to estimate cumulative live-birth rates. Conservative estimates assumed that women who did not return for treatment would not have a live birth; optimal estimates assumed that these women would have live-birth rates similar to those for women continuing treatment.The data were from 246,740 women, with 471,208 cycles and 140,859 live births. Live-birth rates declined with increasing maternal age and increasing cycle number with autologous, but not donor, oocytes. By the third cycle, the conservative and optimal estimates of live-birth rates with autologous oocytes had declined from 63.3% and 74.6%, respectively, for women younger than 31 years of age to 18.6% and 27.8% for those 41 or 42 years of age and to 6.6% and 11.3% for those 43 years of age or older. When donor oocytes were used, the rates were higher than 60% and 80%, respectively, for all ages. Rates were higher with blastocyst embryos (day of transfer, 5 or 6) than with cleavage embryos (day of transfer, 2 or 3). At the third cycle, the conservative and optimal estimates of cumulative live-birth rates were, respectively, 42.7% and 65.3% for transfer of cleavage embryos and 52.4% and 80.7% for transfer of blastocyst embryos when fresh autologous oocytes were used.Our results indicate that live-birth rates approaching natural fecundity can be achieved by means of assisted reproductive technology when there are favorable patient and embryo characteristics. Live-birth rates among older women are lower than those among younger women when autologous oocytes are used but are similar to the rates among young women when donor oocytes are used. (Funded by the National Institutes of Health and the Society for Assisted Reproductive Technology.).

Project description:BackgroundAssisted reproduction technology (ART) has advanced significantly, raising concerns regarding its impact on the secondary sex ratio (SSR), which is the sex ratio at birth in offspring. This study aimed to explore factors affecting SSR in singletons, singletons from twin gestation, and twins from twin gestation within the context of ART.MethodsA retrospective analysis was conducted on data from 8335 births involving 6,223 couples undergoing ART. Binary logistic regression assessed relationships between parental and embryonic factors and SSR in singletons and singletons from twin gestation. Multinomial logistic regression models were utilized to identify factors influencing SSR in twins from twin gestation.ResultsSecondary infertility (OR = 1.164, 95% CI: 1.009-1.342), advanced paternal age (OR = 1.261, 95% CI: 1.038-1.534), and blastocyst embryo transfer (OR = 1.339, 95% CI: 1.030-1.742) were associated with an increased SSR, while frozen embryo transfer (FET) showed a negative association with SSR (OR = 0.738, 95% CI: 0.597-0.912) in singletons. A longer duration of gonadotropin (Gn) usage reduced SSR in singletons (OR = 0.961, 95% CI: 0.932-0.990) and singletons from twin gestation (OR = 0.906, 95% CI: 0.838-0.980). In singletons from twin gestation, male-induced infertility (OR = 2.208, 95% CI: 1.120-4.348) and higher Gn dosage (OR = 1.250, 95% CI: 1.010-1.548) were significantly associated with an increased SSR. Women aged > 35 years and intracytoplasmic sperm injection (ICSI) were associated with lower SSR (OR = 0.539, 95% CI: 0.293-0.990 and OR = 0.331, 95% CI: 0.158-0.690, respectively). In twins from twin gestation, paternal age exceeded maternal age (OR = 0.682, 95% CI: 0.492-0.945) and higher Gn dosage (OR = 0.837, 95% CI: 0.715-0.980) were associated with a higher proportion of male twins. Cleavage stage transfer (OR = 1.754, 95% CI: 1.133-2.716) resulted in a higher percentage of boy-girl twins compared to blastocyst transfer.ConclusionThis study demonstrates the complex interplay of various factors in determining the SSR in ART, highlighting the importance of considering infertility type, paternal age, fertilization method, embryo transfer stage, and Gn use duration when assessing SSR. Nevertheless, further research with a large sample size is necessary to confirm and expand upon the findings of this study.

Project description:BackgroundIntra-Cytoplasmic Sperm Injection (ICSI) has revolutionized the reproductive outcomes for couples with male factor infertility. Especially in azoospermic men, use of ICSI with surgically retrieved testicular sperm has helped them have their own biological child. However, considering the immature nature of testicular sperm safety of testicular sperm has been debated.AimsTo compare reproductive outcomes, neonatal outcomes and the incidence of congenital malformations in children born after intracytoplasmic sperm injection (ICSI), using different sperm origins.Settings and designThis is a retrospective study in which a total of 989 participants were enrolled. Study group (Testicular Sperm Aspiration (TESA) ICSI group) had 552 couples with female partners aged ≤37 and had self gamete cycles. ICSI cycles with ejaculated sperm (EJS) acted as the control group.Materials and methodsAll male patients underwent surgical sperm retrieval and all the women underwent controlled ovarian stimulation and transvaginal oocyte retrieval and Ovum Pick Up (OPU) as per the standard operating procedures of the clinic. Frozen embryo transfer with two good-grade blastocysts, which had shown 100% survival, were transferred in subsequent cycles.Statistical analysis usedThe Student's t-test was performed for age distribution; odds ratio was performed to find the confounding factors.ResultsEmbryonic and reproductive outcomes were comparable and not statistically significant in the study and control groups. Incidence of congenital anomalies was observed in singleton live births and twin live births in both the TESA-ICSI group and the EJS-ICSI group, but the difference was not statistically significant.ConclusionsOur study revealed that congenital malformations in children born out of ICSI using testicular sperm and EJS were similar; no difference was observed in miscarriages between the testicular sperm-ICSI and EJS-ICSI group. Our data suggests that surgical sperm retrieval in couples with male factor infertility does not alter their reproductive outcome.

Dataset Information

Can the peak E2/follicle ratio be a quantitative indicator of pregnancy outcomes following assisted reproductive cycles? A retrospective study.

Publications

Can the peak E2/follicle ratio be a quantitative indicator of pregnancy outcomes following assisted reproductive cycles? A retrospective study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets