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Association of ADRB1 gene polymorphisms with pain sensitivity in a Chinese population.

ABSTRACT: OBJECTIVE:The present study aims to observe the influence of single-nucleotide polymorphisms (SNPs) in the ADRB1 gene on individual differences in pain sensitivity. METHODS:We analyzed the associations between pain sensitivity and ADRB1 gene SNPs (A145 G and G1165 C) in 324 Chinese patients who underwent surgery. The genotyping was performed using PCR-RFLP technique. RESULTS:The patients who carried the A-allele of the A145 G SNP were more sensitive to cold pressor-induced pain than those who did not carry this allele (P < 0.05). We did not found G1165 C polymorphism associated with pain sensitive in the present study. The haplotype analysis revealed A-C haplotype carriers have reduced fentanyl use in 24-h postoperative (P < 0.05). CONCLUSION:ADRB1 gene polymorphisms are associated with pain and analgesic sensitivity.

SUBMITTER: Feng S

PROVIDER: S-EPMC4565355 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Association of ADRB1 gene polymorphisms with pain sensitivity in a Chinese population.

Feng Shuang S Li Nan N Xu Sheng S Wang Hao H Yu Wei W Lu Yan Y Cao Jianping J Meng Yan Y

International journal of clinical and experimental medicine 20150715 7

<h4>Objective</h4>The present study aims to observe the influence of single-nucleotide polymorphisms (SNPs) in the ADRB1 gene on individual differences in pain sensitivity.<h4>Methods</h4>We analyzed the associations between pain sensitivity and ADRB1 gene SNPs (A145 G and G1165 C) in 324 Chinese patients who underwent surgery. The genotyping was performed using PCR-RFLP technique.<h4>Results</h4>The patients who carried the A-allele of the A145 G SNP were more sensitive to cold pressor-induced ...[more]

PMID: 26379972

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