Unknown

Dataset Information

0

Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines.

ABSTRACT: The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relationship study indicated the necessity of the chlorine at the C4-position for biological activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Additionally, the compounds were screened against a variety of other microbial targets and as a result, selective activity against several fungi was also observed. The synthesis and preliminary biological results are reported herein.

SUBMITTER: Temburnikar KW 

PROVIDER: S-EPMC4565497 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relationship study indicated the necessity of the chlorine at the C4-position for biological activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Additionally, the compounds were screened against a variety of other microbial targets and as a result, se  ...[more]

Similar Datasets

Unknown Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines.
| S-EPMC5661880 | biostudies-literature
Unknown 4-Substituted Thieno[3,2-<i>d</i>]pyrimidines as Dual-Stage Antiplasmodial Derivatives.
| S-EPMC9323797 | biostudies-literature
Unknown Anticancer Properties of Halogenated Pyrrolo[3,2-d]pyrimidines with Decreased Toxicity via N5 Substitution.
| S-EPMC5912934 | biostudies-literature
Unknown Mitotic arrest of breast cancer MDA-MB-231 cells by a halogenated thieno[3,2-d]pyrimidine.
| S-EPMC4556284 | biostudies-literature
Unknown Design, Synthesis and Anti-Proliferative Activities of 2,6-Substituted Thieno[3,2-d]pyrimidine Derivatives Containing Electrophilic Warheads.
| S-EPMC6154568 | biostudies-literature
Unknown N-Benzyl-thieno[3,2-d]pyrimidin-4-amine.
| S-EPMC3648234 | biostudies-literature
Unknown Structural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones.
| S-EPMC3125133 | biostudies-literature
Unknown Synthesis and characterization of new thieno[3,2-b]thiophene derivatives.
| S-EPMC6269117 | biostudies-literature
Unknown Efficient solution-phase synthesis of 4,5,7-trisubstituted pyrrolo[3,2-d]pyrimidines.
| S-EPMC3724770 | biostudies-literature
Unknown Organic Thin Film Transistors Incorporating Solution Processable Thieno[3,2-b]thiophene Thienoacenes.
| S-EPMC5793506 | biostudies-literature