Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus.
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ABSTRACT:
SUBMITTER: Altwasser R
PROVIDER: S-EPMC4565559 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus.
Altwasser Robert R Baldin Clara C Weber Jakob J Guthke Reinhard R Kniemeyer Olaf O Brakhage Axel A AA Linde Jörg J Valiante Vito V
PloS one 20150910 9
Mitogen activated protein kinases (MAPKs) are highly conserved in eukaryotic organisms. In pathogenic fungi, their activities were assigned to different physiological functions including drug adaptation and resistance. Aspergillus fumigatus is a human pathogenic fungus, which causes life-threatening invasive infections. Therapeutic options against invasive mycoses are still limited. One of the clinically used drugs is caspofungin, which specifically targets the fungal cell wall biosynthesis. A s ...[more]
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