Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality.
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ABSTRACT:
SUBMITTER: Clark RI
PROVIDER: S-EPMC4565751 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
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Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality.
Clark Rebecca I RI Salazar Anna A Yamada Ryuichi R Fitz-Gibbon Sorel S Morselli Marco M Alcaraz Jeanette J Rana Anil A Rera Michael M Pellegrini Matteo M Ja William W WW Walker David W DW
Cell reports 20150828 10
Alterations in the composition of the intestinal microbiota have been correlated with aging and measures of frailty in the elderly. However, the relationships between microbial dynamics, age-related changes in intestinal physiology, and organismal health remain poorly understood. Here, we show that dysbiosis of the intestinal microbiota, characterized by an expansion of the Gammaproteobacteria, is tightly linked to age-onset intestinal barrier dysfunction in Drosophila. Indeed, alterations in th ...[more]
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