Ontology highlight
ABSTRACT:
SUBMITTER: Moullan N
PROVIDER: S-EPMC4565776 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Moullan Norman N Mouchiroud Laurent L Wang Xu X Ryu Dongryeol D Williams Evan G EG Mottis Adrienne A Jovaisaite Virginija V Frochaux Michael V MV Quiros Pedro M PM Deplancke Bart B Houtkooper Riekelt H RH Auwerx Johan J
Cell reports 20150312 10
In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, the wide range of direct effects of tetracycline use has not been fully appreciated. We show here that these antibiotics induce a mitonuclear protein imbalance through their effects on mitochondrial translation, an effect that likely reflects the evolutionary relationship between mitochondria and proteobacteria. Even at low concentrations, tet ...[more]