Dataset Information

Prognostic value and clinicopathological significance of epithelial cadherin expression in non-small cell lung cancer.

ABSTRACT:

Background

Epithelial cadherin (E-cadherin), a calcium-dependent cell-cell adhesion molecule, as an important adhesion and signaling pathway mediator plays key roles in the maintenance of tissue integrity. However, the available results of E-cadherin expression and its prognostic value on non-small cell lung cancer (NSCLC) remain controversial. Therefore, a meta-analysis of published studies investigating the prognostic value of E-cadherin expression and its association with clinicopathological characteristics with NSCLC was performed.

Methods

A literature search via PubMed, EMBASE, and MEDLINE (Ovid) databases was conducted. Data from eligible studies were extracted. Statistical analysis was performed using STATA 12.0.

Results

A total of 2412 patients from 15 studies were included in the meta-analysis. The results showed that the pooled hazard ratio (HR) for overall survival was 0.55 (95% confidence interval [CI]: 0.44-0.69) by univariate analysis and 0.68 (95% CI: 0.43-1.08) by multivariate analysis. In addition, the results showed a significant association between E-cadherin expression and the presence of lymph node metastasis (odds ratio = 0.37, 95% CI=0.05-0.69, P = 0.001).

Conclusion

Our study showed that positive expression of E-cadherin was associated with a favorable prognosis in patients with NSCLC, and might act as an inhibition factor of metastasis. However, adequately designed prospective studies are required to confirm this finding.

SUBMITTER: Qiu ZX

PROVIDER: S-EPMC4567004 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Publications

Prognostic value and clinicopathological significance of epithelial cadherin expression in non-small cell lung cancer.

Qiu Zhi-Xin ZX Zhao Shuang S Li Lei L Li Wei-Min WM

Thoracic cancer 20150129 5

<h4>Background</h4>Epithelial cadherin (E-cadherin), a calcium-dependent cell-cell adhesion molecule, as an important adhesion and signaling pathway mediator plays key roles in the maintenance of tissue integrity. However, the available results of E-cadherin expression and its prognostic value on non-small cell lung cancer (NSCLC) remain controversial. Therefore, a meta-analysis of published studies investigating the prognostic value of E-cadherin expression and its association with clinicopatho ...[more]

PMID: 26445607

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Dataset Information

Prognostic value and clinicopathological significance of epithelial cadherin expression in non-small cell lung cancer.

Background

Methods

Results

Conclusion

Publications

Prognostic value and clinicopathological significance of epithelial cadherin expression in non-small cell lung cancer.

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