Ontology highlight
ABSTRACT:
SUBMITTER: Zhu D
PROVIDER: S-EPMC4567046 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Zhu Di D Wang Zhongqiu Z Zhao Jian-Jun JJ Calimeri Teresa T Meng Jiang J Hideshima Teru T Fulciniti Mariateresa M Kang Yue Y Ficarro Scott B SB Tai Yu-Tzu YT Hunter Zachary Z McMilin Douglas D Tong Haoxuan H Mitsiades Constantine S CS Wu Catherine J CJ Treon Steven P SP Dorfman David M DM Pinkus Geraldine G Munshi Nikhil C NC Tassone Pierfrancesco P Marto Jarrod A JA Anderson Kenneth C KC Carrasco Ruben D RD
Nature medicine 20150525 6
B cell malignancies frequently colonize the bone marrow. The mechanisms responsible for this preferential homing are incompletely understood. Here we studied multiple myeloma (MM) as a model of a terminally differentiated B cell malignancy that selectively colonizes the bone marrow. We found that extracellular CyPA (eCyPA), secreted by bone marrow endothelial cells (BMECs), promoted the colonization and proliferation of MM cells in an in vivo scaffold system via binding to its receptor, CD147, o ...[more]