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ABSTRACT:
SUBMITTER: Tantak MP
PROVIDER: S-EPMC4567476 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Tantak Mukund P MP Wang Jing J Singh Rajnish Prakash RP Kumar Anil A Shah Kavita K Kumar Dalip D
Bioorganic & medicinal chemistry letters 20150806 19
A new series of 2-(3'-indolyl)-N-arylthiazole-4-carboxamides 17a-p has been designed and synthesized. Initial reaction of readily available thioamides 15 with bromopyruvic acid under refluxing conditions produced different thiazole carboxylic acids 16 which upon coupling with arylamines by using EDCI·HCl and HOBt afforded diverse arylthiazole-4-carboxamides 17a-p in 78-87% yields. Antibacterial activity evaluation against Gram-positive and Gram-negative bacterial strains led to compounds 17i-k a ...[more]