Ontology highlight
ABSTRACT:
SUBMITTER: Bohovych I
PROVIDER: S-EPMC4568518 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Bohovych Iryna I Fernandez Mario R MR Rahn Jennifer J JJ Stackley Krista D KD Bestman Jennifer E JE Anandhan Annadurai A Franco Rodrigo R Claypool Steven M SM Lewis Robert E RE Chan Sherine S L SS Khalimonchuk Oleh O
Scientific reports 20150914
Mitochondria are involved in key cellular functions including energy production, metabolic homeostasis, and apoptosis. Normal mitochondrial function is preserved by several interrelated mechanisms. One mechanism - intramitochondrial quality control (IMQC) - is represented by conserved proteases distributed across mitochondrial compartments. Many aspects and physiological roles of IMQC components remain unclear. Here, we show that the IMQC protease Oma1 is required for the stability of the respir ...[more]