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Repairing Osteochondral Defects of Critical Size Using Multiple Costal Grafts: An Experimental Study.


ABSTRACT:

Objective

To investigate the feasibility of repairing osteochondral defects of critical size by performing mosaicplasty using multiple sliced costal cartilage grafts, which enables repair of extensively injured knees using grafts from a single rib.

Design

Critical osteochondral defects were prepared on the femoral groove of skeletally mature Japanese white rabbits. Costal cartilage grafts from a single rib were harvested and sliced into multiple segments (approximately 3-5 mm in length). The defects were left untreated or repaired by performing mosaicplasty using costal cartilage grafts (with or without a longitudinal cut along the middle). At 4 and 12 weeks after transplantation, International Cartilage Repair Society macroscopic and histological grading was performed.

Results

The macroscopic score and visual histological score were significantly higher in the repaired groups than in the untreated group at 4 and 12 weeks after surgery. Histological continuous integration between grafted costal cartilage and host bone was observed in both repaired groups.

Conclusions

The findings suggest that costal cartilage might be a useful alternative source for chondral grafting. We were able to repair large osteochondral defects by performing mosaicplasty using multiple sliced costal cartilage grafts from a single rib.

SUBMITTER: Du D 

PROVIDER: S-EPMC4568731 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Publications

Repairing Osteochondral Defects of Critical Size Using Multiple Costal Grafts: An Experimental Study.

Du Dajiang D   Sugita Norihiko N   Liu Zhen Z   Moriguchi Yu Y   Nakata Ken K   Myoui Akira A   Yoshikawa Hideki H  

Cartilage 20151001 4


<h4>Objective</h4>To investigate the feasibility of repairing osteochondral defects of critical size by performing mosaicplasty using multiple sliced costal cartilage grafts, which enables repair of extensively injured knees using grafts from a single rib.<h4>Design</h4>Critical osteochondral defects were prepared on the femoral groove of skeletally mature Japanese white rabbits. Costal cartilage grafts from a single rib were harvested and sliced into multiple segments (approximately 3-5 mm in l  ...[more]

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