Gene delivery polymer structure-function relationships elucidated via principal component analysis.
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ABSTRACT:
SUBMITTER: Bishop CJ
PROVIDER: S-EPMC4568840 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Gene delivery polymer structure-function relationships elucidated via principal component analysis.
Bishop C J CJ Abubaker-Sharif B B Guiriba T T Tzeng S Y SY Green J J JJ
Chemical communications (Cambridge, England) 20150801 60
Principal component analysis was applied to a biomaterial library of poly(beta-amino ester)s, useful for non-viral gene delivery, to elucidate chemical parameters that drive biological function. Correlative relationships and principal components were analyzed between 24 physico-chemical polymer properties and 3 cell-based functional variables in human glioblastoma cells (transfection, uptake, and viability). ...[more]
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