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Gene delivery polymer structure-function relationships elucidated via principal component analysis.

ABSTRACT: Principal component analysis was applied to a biomaterial library of poly(beta-amino ester)s, useful for non-viral gene delivery, to elucidate chemical parameters that drive biological function. Correlative relationships and principal components were analyzed between 24 physico-chemical polymer properties and 3 cell-based functional variables in human glioblastoma cells (transfection, uptake, and viability).

SUBMITTER: Bishop CJ 

PROVIDER: S-EPMC4568840 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Gene delivery polymer structure-function relationships elucidated via principal component analysis.

Bishop C J CJ   Abubaker-Sharif B B   Guiriba T T   Tzeng S Y SY   Green J J JJ  

Chemical communications (Cambridge, England) 20150801 60

Principal component analysis was applied to a biomaterial library of poly(beta-amino ester)s, useful for non-viral gene delivery, to elucidate chemical parameters that drive biological function. Correlative relationships and principal components were analyzed between 24 physico-chemical polymer properties and 3 cell-based functional variables in human glioblastoma cells (transfection, uptake, and viability). ...[more]

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