Ontology highlight
ABSTRACT:
SUBMITTER: Palena C
PROVIDER: S-EPMC4568990 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Palena Claudia C Roselli Mario M Litzinger Mary T MT Ferroni Patrizia P Costarelli Leopoldo L Spila Antonella A Cavaliere Francesco F Huang Bruce B Fernando Romaine I RI Hamilton Duane H DH Jochems Caroline C Tsang Kwong-Yok KY Cheng Qing Q Lyerly H Kim HK Schlom Jeffrey J Guadagni Fiorella F
Journal of the National Cancer Institute 20140509 5
<h4>Background</h4>The epithelial-mesenchymal transition (EMT) has been implicated as an important process in tumor cell invasion, metastasis, and drug resistance. The transcription factor brachyury has recently been described as a driver of EMT of human carcinoma cells.<h4>Methods</h4>Brachyury mRNA and protein expression was analyzed in human breast carcinomas and benign tissues. The role of brachyury in breast tumor prognosis and drug resistance and the ability of brachyury-specific T cells t ...[more]