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Transcriptomic Profiling of Spleen in Grass-Fed and Grain-Fed Angus Cattle.


ABSTRACT: The grass-fed cattle obtain nutrients directly from pastures containing limited assimilable energy but abundant amount of fiber; by contrast, grain-fed steers receive a diet that is comprised mainly of grains and serves as an efficient source of high-digestible energy. Besides energy, these two types of diet differ in a large number of nutritional components. Additionally, animals maintained on rich-energy regimen are more likely to develop metabolic disorders and infectious diseases than pasture raised individuals. Thus, we hypothesize that spleen-a relevant immune organ-may function differently under disparate regimes. The objective of this study was to find the differentially expressed genes in the spleen of grass-fed and grain-fed steers, and furtherly explore the potential involved biopathways. Through RNA sequencing (RNA-Seq), we detected 123 differentially expressed genes. Based on these genes, we performed an Ingenuity Pathway Analysis (IPA) and identified 9 significant molecular networks and 13 enriched biological pathways. Two of the pathways, Nur77 signaling in T lymphocytes and calcium-induced T lymphocyte apoptosis which are immune related, contain a pair of genes HLA-DRA and NR4A1 with dramatically altered expression level. Collectively, our results provided valuable insights into understanding the molecular mechanism of spleen under varied feeding regimens.

SUBMITTER: Li Y 

PROVIDER: S-EPMC4569079 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Transcriptomic Profiling of Spleen in Grass-Fed and Grain-Fed Angus Cattle.

Li Yaokun Y   Carrillo José A JA   Ding Yi Y   He Yanghua Y   Zhao Chunping C   Liu Jianan J   Liu George E GE   Zan Linsen L   Song Jiuzhou J  

PloS one 20150914 9


The grass-fed cattle obtain nutrients directly from pastures containing limited assimilable energy but abundant amount of fiber; by contrast, grain-fed steers receive a diet that is comprised mainly of grains and serves as an efficient source of high-digestible energy. Besides energy, these two types of diet differ in a large number of nutritional components. Additionally, animals maintained on rich-energy regimen are more likely to develop metabolic disorders and infectious diseases than pastur  ...[more]

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