Ontology highlight
ABSTRACT:
SUBMITTER: Belin L
PROVIDER: S-EPMC4569274 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20150914 9
For phase II oncology trials, Simon's two-stage design is the most commonly used strategy. However, when clinically unevaluable patients occur, the total number of patients included at each stage differs from what was initially planned. Such situations raise concerns about the operating characteristics of the trial design. This paper evaluates three classical ad hoc strategies and a novel one proposed in this work for handling unevaluable patients. This latter is called the rescue strategy which ...[more]