Ontology highlight
ABSTRACT:
SUBMITTER: McKenzie CW
PROVIDER: S-EPMC4569307 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
McKenzie Casey W CW Craige Branch B Kroeger Tiffany V TV Finn Rozzy R Wyatt Todd A TA Sisson Joseph H JH Pavlik Jacqueline A JA Strittmatter Lara L Hendricks Gregory M GM Witman George B GB Lee Lance L
Molecular biology of the cell 20150729 18
Motile cilia and flagella play critical roles in fluid clearance and cell motility, and dysfunction commonly results in the pediatric syndrome primary ciliary dyskinesia (PCD). CFAP221, also known as PCDP1, is required for ciliary and flagellar function in mice and Chlamydomonas reinhardtii, where it localizes to the C1d projection of the central microtubule apparatus and functions in a complex that regulates flagellar motility in a calcium-dependent manner. We demonstrate that the genes encodin ...[more]