Ontology highlight
ABSTRACT:
SUBMITTER: He Y
PROVIDER: S-EPMC4569314 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
He Yingpei Y Ren Yuan Y Wu Bingbing B Decourt Boris B Lee Aih Cheun AC Taylor Aaron A Suter Daniel M DM
Molecular biology of the cell 20150729 18
Src tyrosine kinases have been implicated in axonal growth and guidance; however, the underlying cellular mechanisms are not well understood. Specifically, it is unclear which aspects of actin organization and dynamics are regulated by Src in neuronal growth cones. Here, we investigated the function of Src2 and one of its substrates, cortactin, in lamellipodia and filopodia of Aplysia growth cones. We found that up-regulation of Src2 activation state or cortactin increased lamellipodial length, ...[more]