Ontology highlight
ABSTRACT:
SUBMITTER: Pradhan-Sundd T
PROVIDER: S-EPMC4569321 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Pradhan-Sundd Tirthadipa T Verheyen Esther M EM
Molecular biology of the cell 20150729 18
Endosomal trafficking of signaling proteins plays an essential role in cellular homeostasis. The seven-pass transmembrane protein Frizzled (Fz) is a critical component of Wnt signaling. Although Wnt signaling is proposed to be regulated by endosomal trafficking of Fz, the molecular events that enable this regulation are not completely understood. Here we show that the endosomal protein Myopic (Mop) regulates Fz trafficking in the Drosophila wing disk by inhibiting the ubiquitination and degradat ...[more]