Ontology highlight
ABSTRACT:
SUBMITTER: Ishibashi D
PROVIDER: S-EPMC4569470 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ishibashi Daisuke D Homma Takujiro T Nakagaki Takehiro T Fuse Takayuki T Sano Kazunori K Takatsuki Hanae H Atarashi Ryuichiro R Nishida Noriyuki N
PloS one 20150914 9
Prion diseases are neurodegenerative disorders caused by the accumulation of abnormal prion protein (PrPSc) in the central nervous system. With the aim of elucidating the mechanism underlying the accumulation and degradation of PrPSc, we investigated the role of autophagy in its degradation, using cultured cells stably infected with distinct prion strains. The effects of pharmacological compounds that inhibit or stimulate the cellular signal transduction pathways that mediate autophagy during Pr ...[more]