Ontology highlight
ABSTRACT:
SUBMITTER: Anjum RS
PROVIDER: S-EPMC4569737 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Nature communications 20150908
In eukaryotes, the covalent attachment of ubiquitin chains directs substrates to the proteasome for degradation. Recently, ubiquitin-like modifications have also been described in the archaeal domain of life. It has subsequently been hypothesized that ubiquitin-like proteasomal degradation might also operate in these microbes, since all archaeal species utilize homologues of the eukaryotic proteasome. Here we perform a structural and biochemical analysis of a ubiquitin-like modification pathway ...[more]