Full-length infectious clone of a low passage dengue virus serotype 2 from Brazil.
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ABSTRACT:
SUBMITTER: Santos JJ
PROVIDER: S-EPMC4569833 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
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Full-length infectious clone of a low passage dengue virus serotype 2 from Brazil.
Santos Jefferson José da Silva JJ Magalhães Tereza T Silva Junior José Valter Joaquim JV Silva Andréa Nazaré Monteiro Rangel da AN Cordeiro Marli Tenório MT Gil Laura Helena Vega Gonzales LH
Memorias do Instituto Oswaldo Cruz 20150717 5
Full-length dengue virus (DENV) cDNA clones are an invaluable tool for many studies, including those on the development of attenuated or chimeric vaccines and on host-virus interactions. Furthermore, the importance of low passage DENV infectious clones should be highlighted, as these may harbour critical and unique strain-specific viral components from field-circulating isolates. The successful construction of a functional Brazilian low passage DENV serotype 2 full-length clone through homologou ...[more]
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