Ontology highlight
ABSTRACT:
SUBMITTER: Ji P
PROVIDER: S-EPMC4569881 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20150727 9
Signal transducer and activator of transcription 3 (STAT3) is considered to be an attractive therapeutic target for cancer therapy. In this study, a series of 2-carbonylbenzo[b]thiophene 1,1-dioxide derivatives (CBT) were designed to inhibit the STAT3 SH2 domain phosphorylation site Try 705. We demonstrated that incorporation of basic flexible groups through amide bond linkage to benzo[b]thiophene 1,1-dioxide (BTP) achieved compounds with higher antiproliferative potency than BTP itself. The mos ...[more]