IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer.
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ABSTRACT:
SUBMITTER: Lunardi S
PROVIDER: S-EPMC4570127 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer.
Lunardi Serena S Lim Su Yin SY Muschel Ruth J RJ Brunner Thomas B TB
Oncoimmunology 20150402 9
Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10. ...[more]
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