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IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer.

ABSTRACT: Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.

SUBMITTER: Lunardi S 

PROVIDER: S-EPMC4570127 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer.

Lunardi Serena S   Lim Su Yin SY   Muschel Ruth J RJ   Brunner Thomas B TB  

Oncoimmunology 20150402 9

Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10. ...[more]

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