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Structure-function correlations in tyrosinases.

ABSTRACT: Tyrosinases are metalloenzymes belonging to the type-3 copper protein family which contain two copper ions in the active site. They are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. Two other members of this family are catechol oxidases, which are prevalent mainly in plants and perform only the second oxidation step, and hemocyanins, which lack enzymatic activity and are oxygen carriers. In the last decade, several structures of plant and bacterial tyrosinases were determined, some with substrates or inhibitors, highlighting features and residues which are important for copper uptake and catalysis. This review summarizes the updated information on structure-function correlations in tyrosinases along with comparison to other type-3 copper proteins.

SUBMITTER: Kanteev M

PROVIDER: S-EPMC4570531 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Structure-function correlations in tyrosinases.

Kanteev Margarita M Goldfeder Mor M Fishman Ayelet A

Protein science : a publication of the Protein Society 20150707 9

Tyrosinases are metalloenzymes belonging to the type-3 copper protein family which contain two copper ions in the active site. They are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. Two ot ...[more]

PMID: 26104241

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Dataset Information

Structure-function correlations in tyrosinases.

Publications

Structure-function correlations in tyrosinases.

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