Ontology highlight
ABSTRACT:
SUBMITTER: Lu NT
PROVIDER: S-EPMC4570757 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Journal for immunotherapy of cancer 20150915
We describe the clinical and therapeutic course of a 51-year-old woman with HER-2+ breast cancer who developed leptomeningeal (LM) and spinal cord metastases after 8 years of stable disease on combination therapy with intravenous (IV) trastuzumab. Due to progressive CNS disease, intrathecal (IT) trastuzumab was introduced to enhance HER-2+ therapy into the CSF space. A combination HER-2+ targeted approach achieved clinical remission with stable disease in our patient 46 months after she was diag ...[more]