Ontology highlight
ABSTRACT:
SUBMITTER: Hall DD
PROVIDER: S-EPMC4570828 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Hall Duane D DD Dai Shuiping S Tseng Pang-Yen PY Malik Zulfiqar Z Nguyen Minh M Matt Lucas L Schnizler Katrin K Shephard Andrew A Mohapatra Durga P DP Tsuruta Fuminori F Dolmetsch Ricardo E RE Christel Carl J CJ Lee Amy A Burette Alain A Weinberg Richard J RJ Hell Johannes W JW
Neuron 20130501 3
Regulation of neuronal excitability and cardiac excitation-contraction coupling requires the proper localization of L-type Ca²⁺ channels. We show that the actin-binding protein α-actinin binds to the C-terminal surface targeting motif of α11.2, the central pore-forming Ca(V)1.2 subunit, in order to foster its surface expression. Disruption of α-actinin function by dominant-negative or small hairpin RNA constructs reduces Ca(V)1.2 surface localization in human embryonic kidney 293 and neuronal cu ...[more]