Ontology highlight
ABSTRACT:
SUBMITTER: Lazo-Fernandez Y
PROVIDER: S-EPMC4572452 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Lazo-Fernandez Yoskaly Y Aguilera Greti G Pham Truyen D TD Park Annie Y AY Beierwaltes William H WH Sutliff Roy L RL Verlander Jill W JW Pacak Karel K Osunkoya Adeboye O AO Ellis Carla L CL Kim Young Hee YH Shipley Gregory L GL Wynne Brandi M BM Hoover Robert S RS Sen Shurjo K SK Plotsky Paul M PM Wall Susan M SM
American journal of physiology. Endocrinology and metabolism 20150714 6
Pendrin (Slc26a4) is a Cl(-)/HCO3 (-) exchanger expressed in renal intercalated cells and mediates renal Cl(-) absorption. With pendrin gene ablation, blood pressure and vascular volume fall, which increases plasma renin concentration. However, serum aldosterone does not significantly increase in pendrin-null mice, suggesting that pendrin regulates adrenal zona glomerulosa aldosterone production. Therefore, we examined pendrin expression in the adrenal gland using PCR, immunoblots, and immunohis ...[more]