Dataset Information

Genetic variants in the major histocompatibility complex class I and class II genes are associated with diisocyanate-induced Asthma.

ABSTRACT:

Objective

To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA).

Methods

The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels.

Results

The HLA-E rs1573294 and HLA-DPB1 rs928976 SNPs were associated with an increased risk of DA under dominant (odds ratio [OR], 6.27; 95% confidence interval [CI], 2.37 to 16.6; OR, 2.79, 95% CI, 0.99 to 7.81, respectively) and recessive genetic models (OR, 6.27, 95% CI, 1.63 to 24.13; OR, 10.10, 95% CI, 3.16 to 32.33, respectively). The HLA-B rs1811197, HLA-DOA rs3128935, and HLA-DQA2 rs7773955 SNPs conferred an increased risk of DA in a dominant model (OR, 7.64, 95% CI, 2.25 to 26.00; OR, 19.69, 95% CI, 2.89 to 135.25; OR, 8.43, 95% CI, 3.03 to 23.48, respectively).

Conclusion

These results suggest that genetic variations within HLA genes play a role in DA risk.

SUBMITTER: Yucesoy B

PROVIDER: S-EPMC4572490 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Publications

Genetic variants in the major histocompatibility complex class I and class II genes are associated with diisocyanate-induced Asthma.

Yucesoy Berran B Johnson Victor J VJ Lummus Zana L ZL Kashon Michael L ML Rao Marepalli M Bannerman-Thompson Hansen H Frye Bonnie B Wang Wei W Gautrin Denyse D Cartier André A Boulet Louis-Philippe LP Sastre Joaquin J Quirce Santiago S Tarlo Susan M SM Germolec Dori R DR Luster Michael I MI Bernstein David I DI

Journal of occupational and environmental medicine 20140401 4

<h4>Objective</h4>To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA).<h4>Methods</h4>The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels.<h4>Results</h4>The HLA-E rs1573294 and HLA-DPB1 rs928976 SNPs were associated with an increased risk of DA under domi ...[more]

PMID: 24709764

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Dataset Information

Genetic variants in the major histocompatibility complex class I and class II genes are associated with diisocyanate-induced Asthma.

Objective

Methods

Results

Conclusion

Publications

Genetic variants in the major histocompatibility complex class I and class II genes are associated with diisocyanate-induced Asthma.

Similar Datasets

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