Ontology highlight
ABSTRACT:
SUBMITTER: Soave D
PROVIDER: S-EPMC4572492 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
American journal of human genetics 20150701 1
Gene-based, pathway, and other multivariate association methods are motivated by the possibility of GxG and GxE interactions; however, accounting for such interactions is limited by the challenges associated with adequate modeling information. Here we propose an easy-to-implement joint location-scale (JLS) association testing framework for single-variant and multivariate analysis that accounts for interactions without explicitly modeling them. We apply the JLS method to a gene-set analysis of cy ...[more]