Ontology highlight
ABSTRACT:
SUBMITTER: Benham-Pyle BW
PROVIDER: S-EPMC4572847 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Benham-Pyle Blair W BW Pruitt Beth L BL Nelson W James WJ
Science (New York, N.Y.) 20150501 6238
Mechanical strain regulates the development, organization, and function of multicellular tissues, but mechanisms linking mechanical strain and cell-cell junction proteins to cellular responses are poorly understood. Here, we showed that mechanical strain applied to quiescent epithelial cells induced rapid cell cycle reentry, mediated by independent nuclear accumulation and transcriptional activity of first Yap1 and then β-catenin. Inhibition of Yap1- and β-catenin-mediated transcription blocked ...[more]