Ontology highlight
ABSTRACT:
SUBMITTER: Nead KT
PROVIDER: S-EPMC4572886 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Nead Kevin T KT Sharp Stephen J SJ Thompson Deborah J DJ Painter Jodie N JN Savage David B DB Semple Robert K RK Barker Adam A Perry John R B JR Attia John J Dunning Alison M AM Easton Douglas F DF Holliday Elizabeth E Lotta Luca A LA O'Mara Tracy T McEvoy Mark M Pharoah Paul D P PD Scott Rodney J RJ Spurdle Amanda B AB Langenberg Claudia C Wareham Nicholas J NJ Scott Robert A RA
Journal of the National Cancer Institute 20150701 9
<h4>Background</h4>Insulinemia and type 2 diabetes (T2D) have been associated with endometrial cancer risk in numerous observational studies. However, the causality of these associations is uncertain. Here we use a Mendelian randomization (MR) approach to assess whether insulinemia and T2D are causally associated with endometrial cancer.<h4>Methods</h4>We used single nucleotide polymorphisms (SNPs) associated with T2D (49 variants), fasting glucose (36 variants), fasting insulin (18 variants), e ...[more]