Ontology highlight
ABSTRACT:
SUBMITTER: Graustein AD
PROVIDER: S-EPMC4573533 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Graustein A D AD Horne D J DJ Arentz M M Bang N D ND Chau T T H TT Thwaites G E GE Caws M M Thuong N T T NT Dunstan S J SJ Hawn T R TR
Tuberculosis (Edinburgh, Scotland) 20150107 2
Humans exposed to Mycobacterium tuberculosis (Mtb) show variation in susceptibility to infection and differences in tuberculosis (TB) disease outcome. Toll-like receptor 9 (TLR9) is a pattern recognition receptor that mediates recognition of Mtb and modulates Mtb-specific T-cell responses. Using a case-population design, we evaluated whether single nucleotide polymorphisms (SNPs) in the TLR9 gene region are associated with susceptibility to pulmonary or meningeal TB as well as neurologic present ...[more]