Dataset Information

Weakening of Corticomuscular Signal Coupling During Voluntary Motor Action in Aging.

ABSTRACT:

Background

Aging is associated with muscle weakness and impairment in performing skilled motor tasks. Still, little is known about whether the link or functional coupling or connection between the central and peripheral systems during voluntary motor performance is compromised in the elderly subjects. The purposes of this study were to estimate functional corticomuscular connection (CMC) strength in the elderly subjects by calculating EEG-EMG coherence during voluntary motor performance, determine the relationship between the CMC and voluntary muscle force, and compare these between the old and the young subjects.

Methods

Maximal voluntary contraction (MVC) of elbow flexion (EF) and EFs at three submaximal (20%, 50%, and 80% MVC) levels were performed in 28 healthy older (74.96±1.32 years) and 20 young (22.60±0.90 years) individuals, while EEG and EMG from biceps brachii, brachioradialis, and triceps brachii muscles were recorded simultaneously.

Results

Compared with the young, older individuals exhibited significantly weakened CMC at all force levels tested. There was a proportional relationship between the CMC and EF force and high-positive correlation between the CMC and EF strength in both groups.

Conclusions

Weakened CMC in aging may be a major factor contributing to age-related muscle weakness, and the linear relationship between the CMC and voluntary muscle force suggests dependence of force output on translation of the descending command to muscle electrical signal.

SUBMITTER: Bayram MB

PROVIDER: S-EPMC4573669 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Publications

Weakening of Corticomuscular Signal Coupling During Voluntary Motor Action in Aging.

Bayram Mehmed Bugrahan MB Siemionow Vlodek V Yue Guang H GH

The journals of gerontology. Series A, Biological sciences and medical sciences 20150316 8

<h4>Background</h4>Aging is associated with muscle weakness and impairment in performing skilled motor tasks. Still, little is known about whether the link or functional coupling or connection between the central and peripheral systems during voluntary motor performance is compromised in the elderly subjects. The purposes of this study were to estimate functional corticomuscular connection (CMC) strength in the elderly subjects by calculating EEG-EMG coherence during voluntary motor performance, ...[more]

PMID: 25779095

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Project description:Parkinson's disease (PD) is typically diagnosed and evaluated on the basis of overt motor dysfunction, however, subtle changes in the frequency spectrum of neural drive to muscles have been reported as well. During dynamic actions, coactive muscles of healthy adults often share a common source of 6-15 Hz (alpha-band) neural drive, creating synchronous alpha-band activity in their EMG signals. Individuals with PD commonly exhibit kinetic action tremor at similar frequencies, but the potential relationship between the intermuscular alpha-band neural drive seen in healthy adults and the action tremor associated with PD is not well-understood. A close relationship is most tenable during voluntary dynamic tasks where alpha-band neural drive is strongest in healthy adults, and where neural circuits affected by PD are most engaged. In this study, we characterized the frequency spectrum of EMG synchronization (intermuscular coherence) in 16 participants with PD and 15 age-matched controls during two dynamic motor tasks: (1) rotation of a dial between the thumb and index finger, and (2) dynamic scaling of isometric precision pinch force. These tasks produce different profiles of coherence between the first dorsal interosseous and abductor pollicis brevis muscles. We sought to determine if alpha-band intermuscular coherence would be amplified in participants with PD relative to controls, if such differences would be task-specific, and if they would correlate with symptom severity. We found that relative to controls, the PD group displayed amplified, but similarly task-dependent, coherence in the alpha-band. The magnitude of coherence during the rotation task correlated with overall symptom severity as per the UPDRS rating scale. Finally, we explored the potential for our coherence measures, with no additional information, to discriminate individuals with PD from controls. The area under the Receiver Operating Characteristic curve (AUC) indicated a clear separation between groups (AUC = 0.96), even though participants with PD were on their typical medication and displayed only mild-moderate symptoms. We conclude that a task-dependent, intermuscular neural drive within the alpha-band is amplified in PD. Its quantification via intermuscular coherence analysis may provide a useful tool for detecting the presence of PD, or assessing its progression.

Dataset Information

Weakening of Corticomuscular Signal Coupling During Voluntary Motor Action in Aging.

Background

Methods

Results

Conclusions

Publications

Weakening of Corticomuscular Signal Coupling During Voluntary Motor Action in Aging.

Similar Datasets

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