Ontology highlight
ABSTRACT:
SUBMITTER: Simoes-Costa M
PROVIDER: S-EPMC4573882 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Simões-Costa Marcos M Stone Michael M Bronner Marianne E ME
Developmental cell 20150806 5
Neural crest cells are induced at the neural plate border by the combined action of transcription factors and signaling molecules. Here, we show that Axud1, a downstream effector of Wnt signaling, represents a critical missing link that integrates signaling and transcriptional cues to mediate neural crest formation. Axud1 is a transcription factor expressed in neural crest progenitors in a Wnt1/β-catenin-dependent manner. Axud1 loss leads to downregulation of multiple genes involved in neural cr ...[more]