Micronutrients Involved in One-Carbon Metabolism and Risk of Breast Cancer Subtypes.

ABSTRACT:

Background

Vitamins involved in one-carbon metabolism are hypothesized to influence breast cancer (BC) risk. However, epidemiologic studies that examined associations between B vitamin intake and BC risk have provided inconsistent results. We prospectively examined, in the Italian ORDET cohort, whether B vitamin consumption was associated with risk of BC and BC subtypes.

Methods

After a mean follow-up of 16.5 years, 391 BCs were diagnosed among 10,786 cohort women. B vitamin intakes were estimated from food frequency questionnaires. Cox proportional hazard models adjusted for energy intake and confounders, estimated hazard ratios (HR) with 95% confidence intervals (CIs) for BC according to intake.

Results

RRs were 0.61 (95% CI 0.38-0.97 highest vs. lowest quartile; P

SUBMITTER: Cancarini I 

PROVIDER: S-EPMC4574438 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature