Ontology highlight
ABSTRACT:
SUBMITTER: Belharazem D
PROVIDER: S-EPMC4574807 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Belharazem Djeda D Schalke Berthold B Gold Ralf R Nix Wilfred W Vitacolonna Mario M Hohenberger Peter P Roessner Eric E Schulze Torsten J TJ Saruhan-Direskeneli Güher G Yilmaz Vuslat V Ott German G Ströbel Philipp P Marx Alexander A
Annals of clinical and translational neurology 20150722 9
<h4>Objective</h4>The capacity of thymomas to generate mature CD4+ effector T cells from immature precursors inside the tumor and export them to the blood is associated with thymoma-associated myasthenia gravis (TAMG). Why TAMG(+) thymomas generate and export more mature CD4+ T cells than MG(-) thymomas is unknown.<h4>Methods</h4>Unfixed thymoma tissue, thymocytes derived thereof, peripheral blood mononuclear cells (PBMCs), T-cell subsets and B cells were analysed using qRT-PCR and western blott ...[more]