Ontology highlight
ABSTRACT:
SUBMITTER: Liapis V
PROVIDER: S-EPMC4574867 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Liapis Vasilios V Labrinidis Agatha A Zinonos Irene I Hay Shelley S Ponomarev Vladimir V Panagopoulos Vasilios V DeNichilo Mark M Ingman Wendy W Atkins Gerald J GJ Findlay David M DM Zannettino Andrew C W ACW Evdokiou Andreas A
Cancer letters 20141115 1
Tumor hypoxia is a major cause of treatment failure for a variety of malignancies. However, tumor hypoxia also offers treatment opportunities, exemplified by the development compounds that target hypoxic regions within tumors. TH-302 is a pro-drug created by the conjugation of 2-nitroimidazole to bromo-isophosphoramide (Br-IPM). When TH-302 is delivered to regions of hypoxia, Br-IPM, the DNA cross linking toxin, is released. In this study we assessed the cytotoxic activity of TH-302 against oste ...[more]