Ontology highlight
ABSTRACT:
SUBMITTER: Porter JR
PROVIDER: S-EPMC4575156 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Porter Justin R JR Weitzner Brian D BD Lange Oliver F OF
PloS one 20150918 9
A core task in computational structural biology is the search of conformational space for low energy configurations of a biological macromolecule. Because conformational space has a very high dimensionality, the most successful search methods integrate some form of prior knowledge into a general sampling algorithm to reduce the effective dimensionality. However, integrating multiple types of constraints can be challenging. To streamline the incorporation of diverse constraints, we developed the ...[more]