Ontology highlight
ABSTRACT:
SUBMITTER: Ni Y
PROVIDER: S-EPMC4575256 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Ni Yang Y Stingo Francesco C FC Baladandayuthapani Veerabhadran V
Biometrics 20150408 3
Gene regulatory networks represent the regulatory relationships between genes and their products and are important for exploring and defining the underlying biological processes of cellular systems. We develop a novel framework to recover the structure of nonlinear gene regulatory networks using semiparametric spline-based directed acyclic graphical models. Our use of splines allows the model to have both flexibility in capturing nonlinear dependencies as well as control of overfitting via shrin ...[more]