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TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.

ABSTRACT: The cellular and molecular events that drive the early development of innate lymphoid cells (ILCs) remain poorly understood. We show that the transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their precursors. Using novel reporter mice, we identified a new subset of early ILC progenitors (EILPs) expressing high amounts of TCF-1. EILPs lacked efficient T and B lymphocyte potential but efficiently gave rise to NK cells and all known adult helper ILC lineages, indicating that they are the earliest ILC-committed progenitors identified so far. Our results suggest that upregulation of TCF-1 expression denotes the earliest stage of ILC fate specification. The discovery of EILPs provides a basis for deciphering additional signals that specify ILC fate.

SUBMITTER: Yang Q

PROVIDER: S-EPMC4575643 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.

Yang Qi Q Li Fengyin F Harly Christelle C Xing Shaojun S Ye Longyun L Xia Xuefeng X Wang Haikun H Wang Xinxin X Yu Shuyang S Zhou Xinyuan X Cam Maggie M Xue Hai-Hui HH Bhandoola Avinash A

Nature immunology 20150817 10

The cellular and molecular events that drive the early development of innate lymphoid cells (ILCs) remain poorly understood. We show that the transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their precursors. Using novel reporter mice, we identified a new subset of early ILC progenitors (EILPs) expressing high amounts of TCF-1. EILPs lacked efficient T and B lymphocyte potential but efficiently gave rise to NK cells and all known adult helper ...[more]

PMID: 26280998

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