Deletion of myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-relevant retinal phenotype.
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ABSTRACT:
SUBMITTER: Schubert T
PROVIDER: S-EPMC4575690 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
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Deletion of myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-relevant retinal phenotype.
Schubert Timm T Gleiser Corinna C Heiduschka Peter P Franz Christoph C Nagel-Wolfrum Kerstin K Sahaboglu Ayse A Weisschuh Nicole N Eske Gordon G Rohbock Karin K Rieger Norman N Paquet-Durand François F Wissinger Bernd B Wolfrum Uwe U Hirt Bernhard B Singer Wibke W Rüttiger Lukas L Zimmermann Ulrike U Knipper Marlies M
Cellular and molecular life sciences : CMLS 20150506 20
The unconventional myosin VI, a member of the actin-based motor protein family of myosins, is expressed in the retina. Its deletion was previously shown to reduce amplitudes of the a- and b-waves of the electroretinogram. Analyzing wild-type and myosin VI-deficient Snell's Waltzer mice in more detail, the expression pattern of myosin VI in retinal pigment epithelium, outer limiting membrane, and outer plexiform layer could be linked with differential progressing ocular deficits. These encompasse ...[more]
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