Ontology highlight
ABSTRACT:
SUBMITTER: Sakoulas G
PROVIDER: S-EPMC4576044 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Sakoulas George G Kumaraswamy Monika M Nonejuie Poochit P Werth Brian J BJ Rybak Micahel J MJ Pogliano Joseph J Rice Louis B LB Nizet Victor V
Antimicrobial agents and chemotherapy 20150720 10
Beta-lactam antibiotics sensitize Enterococcus faecium to killing by endogenous antimicrobial peptides (AMPs) of the innate immune system and daptomycin through mechanisms yet to be elucidated. It has been speculated that beta-lactam inactivation of select E. faecium penicillin binding proteins (PBPs) may play a pivotal role in this sensitization process. To characterize the specific PBP inactivation that may be responsible for these phenotypes, we utilized a previously characterized set of E. f ...[more]