Ontology highlight
ABSTRACT:
SUBMITTER: Kloprogge F
PROVIDER: S-EPMC4576090 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Kloprogge Frank F McGready Rose R Hanpithakpong Warunee W Blessborn Daniel D Day Nicholas P J NP White Nicholas J NJ Nosten François F Tarning Joel J
Antimicrobial agents and chemotherapy 20150803 10
Artemether-lumefantrine is the most widely used antimalarial artemisinin-based combination treatment. Recent studies have suggested that day 7 plasma concentrations of the potent metabolite desbutyl-lumefantrine correlate better with treatment outcomes than those of lumefantrine. Low cure rates have been reported in pregnant women with uncomplicated falciparum malaria treated with artemether-lumefantrine in northwest Thailand. A simultaneous pharmacokinetic drug-metabolite model was developed ba ...[more]