Ontology highlight
ABSTRACT:
SUBMITTER: Branco J
PROVIDER: S-EPMC4576118 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Branco Joana J Silva Ana P AP Silva Raquel M RM Silva-Dias Ana A Pina-Vaz Cidália C Butler Geraldine G Rodrigues Acácio G AG Miranda Isabel M IM
Antimicrobial agents and chemotherapy 20150727 10
Candida parapsilosis is the second most prevalent fungal agent causing bloodstream infections. Nevertheless, there is little information about the molecular mechanisms underlying azole resistance in this species. Mutations (G1747A, A2619C, and A3191C) in the MRR1 transcription factor gene were identified in fluconazole- and voriconazole-resistant strains. Independent expression of MRR1 genes harboring these mutations showed that G1747A (G583R) and A2619C (K873N) are gain-of-function mutations re ...[more]