Epigenetic silencing of tumor suppressor genes during in vitro Epstein-Barr virus infection.
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ABSTRACT:
SUBMITTER: Saha A
PROVIDER: S-EPMC4577197 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Epigenetic silencing of tumor suppressor genes during in vitro Epstein-Barr virus infection.
Saha Abhik A Jha Hem C HC Upadhyay Santosh K SK Robertson Erle S ES
Proceedings of the National Academy of Sciences of the United States of America 20150831 37
DNA-methylation at CpG islands is one of the prevalent epigenetic alterations regulating gene-expression patterns in mammalian cells. Hypo- or hypermethylation-mediated oncogene activation, or tumor suppressor gene (TSG) silencing mechanisms, widely contribute to the development of multiple human cancers. Furthermore, oncogenic viruses, including Epstein-Barr virus (EBV)-associated human cancers, were also shown to be influenced by epigenetic modifications on the viral and cellular genomes in th ...[more]
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