Ontology highlight
ABSTRACT:
SUBMITTER: Belin BJ
PROVIDER: S-EPMC4577826 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Belin Brittany J BJ Lee Terri T Mullins R Dyche RD
eLife 20150819
Actin filaments assemble inside the nucleus in response to multiple cellular perturbations, including heat shock, protein misfolding, integrin engagement, and serum stimulation. We find that DNA damage also generates nuclear actin filaments-detectable by phalloidin and live-cell actin probes-with three characteristic morphologies: (i) long, nucleoplasmic filaments; (ii) short, nucleolus-associated filaments; and (iii) dense, nucleoplasmic clusters. This DNA damage-induced nuclear actin assembly ...[more]